Senolytic Plan


Reduce Senescent Cell Burden

The regeneration of cells is a crucial process for the proper functioning of our bodies. As we grow older, some cells die, while others are created to replace them. However, sometimes the process of creating new cells can go awry, resulting in the formation of damaged cells that remain in our bodies.

These damaged cells, known as senescent cells, can have a detrimental effect on the surrounding cells by disrupting their normal functioning. Senescent cells tend to accumulate, causing inflammation and disrupting the normal functioning of the cells around them. The presence of senescent cells impacts how neighboring cells handle inflammation, sugars and proteins. This can lead to metabolic issues and the emergence of age-related chronic ailments.

These chronic ailments may include conditions such as cardiovascular disease, Alzheimer's disease, and osteoarthritis. We can now slow down or prevent the development of age-related chronic ailments with proper care and treatment.

How Can Senolytics Help?

Senolytics are a revolutionary treatment that has the potential to transform the way we age. By disabling the mechanism that allows senescent cells to survive, senolytics can help us eliminate these harmful cells from our bodies. With senolytics, we can unlock a new era of health and vitality, free from the burden of aging.

Often, a build-up of senescent cells is linked to obesity, metabolic diseases, and the senescence-associated secretory phenotype (SASP). By introducing senolytics to the body, it can reduce adipose tissue dysfunction and inflammation.

The field of senolytics is advancing rapidly with the discovery of the first drugs targeting senescent cells. Dasatinib, Quercetin, Rapamycin, Fisetin, and Navitoclax were all discovered using a hypothesis-driven approach.

Among them, Dasatinib, sold under the name Sprycel, is a cancer medication that helps eliminate senescent cells by inhibiting the Src tyrosine kinase.

Quercetin, a natural flavonoid, is a nutritional supplement that also targets senescent cells by inhibiting the anti-apoptotic protein Bcl-xL.

The combination of these drugs can effectively eliminate senescent cells that are responsible for multiple age-related chronic diseases. This is a promising development in medical science, and more research is needed to discover new senolytic drugs that can help improve overall health and longevity.